The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing.

Ítems similars

• U6atac snRNA, the highly divergent counterpart of U6 snRNA, is the specific target that mediates inhibition of AT-AC splicing by the influenza virus NS1 protein.
  per: Wang, W, et al.
  Publicat: (1998)
• Proximity of conserved U6 and U2 snRNA elements to the 5′ splice site region in activated spliceosomes
  per: Rhode, Britta M, et al.
  Publicat: (2006)
• Discrete domains of human U6 snRNA required for the assembly of U4/U6 snRNP and splicing complexes.
  per: Bindereif, A, et al.
  Publicat: (1990)
• The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export.
  per: Segref, A, et al.
  Publicat: (2001)
• U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone.
  per: Yu, Y T, et al.
  Publicat: (1995)