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Direct and metabolism-dependent toxicity of sulphasalazine and its principal metabolites towards human erythrocytes and leucocytes.

1. The role of metabolites in sulphasalazine-mediated toxicity has been investigated in vitro by the use of human red blood cells and mononuclear leucocytes as target cells, with methaemoglobin formation and cytotoxicity respectively, being the defined toxic end-points. 2. Of the metabolites of sulp...

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Sonraí Bibleagrafaíochta
Main Authors: Pirmohamed, M, Coleman, M D, Hussain, F, Breckenridge, A M, Park, B K
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1991
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1368522/
https://ncbi.nlm.nih.gov/pubmed/1685664
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