Rigidity Sensing at the Leading Edge through α(v)β(3) Integrins and RPTPα

Cells require optimal substrate stiffness for normal function and differentiation. The mechanisms for sensing matrix rigidity and durotaxis, however, are not clear. Here we showed that control, Shp2(−/−), integrin β1(−/−), and talin1(−/−) cell lines all spread to a threefold greater area on fibronec...

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Bibliografiske detaljer
Main Authors: Jiang, Guoying, Huang, Angela H., Cai, Yunfei, Tanase, Monica, Sheetz, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2006
Fag:
Cell Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367329/
https://ncbi.nlm.nih.gov/pubmed/16339875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.072462
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