Apyrase, the Product of the Virulence Plasmid-Encoded phoN2 (apy) Gene of Shigella flexneri, Is Necessary for Proper Unipolar IcsA Localization and for Efficient Intercellular Spread

The role in virulence of the Shigella flexneri ospB-phoN2 operon has been evaluated. Here we confirm that OspB is an effector and show that apyrase, the product of phoN2, may be a virulence factor, since it is required for efficient intercellular spreading. Apyrase may be important in a deoxynucleos...

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Detalhes bibliográficos
Main Authors: Santapaola, D., Del Chierico, F., Petrucca, A., Uzzau, S., Casalino, M., Colonna, B., Sessa, R., Berlutti, F., Nicoletti, M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Molecular Biology of Pathogens
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367242/
https://ncbi.nlm.nih.gov/pubmed/16452446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.188.4.1620-1627.2006
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