Deacetylation of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer and a Decrease in LAT Abundance Precede an Increase in ICP0 Transcriptional Permissiveness at Early Times Postexplant

Only the latency-associated transcript (LAT) of the herpes simplex virus type 1 (HSV-1) genome is transcribed during latency, while the lytic genes are suppressed, possibly by LAT antisense mechanisms and/or chromatin modifications. In the present study, latently infected dorsal root ganglia were ex...

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Detalhes bibliográficos
Main Authors: Amelio, Antonio L., Giordani, Nicole V., Kubat, Nicole J., O'Neil, Jerome E., Bloom, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367155/
https://ncbi.nlm.nih.gov/pubmed/16439563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.4.2063-2068.2006
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