Nuclear Import of Epstein-Barr Virus Nuclear Antigen 1 Mediated by NPI-1 (Importin α5) Is Up- and Down-Regulated by Phosphorylation of the Nuclear Localization Signal for Which Lys379 and Arg380 Are Essential

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1) is essential for replication of episomal EBV DNAs and maintenance of latency. Multifunctional EBNA-1 is phosphorylated, but the significance of EBNA-1 phosphorylation is not known. Here, we examined the effects on nuclear translocation of Ser phosp...

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Detalhes bibliográficos
Main Authors: Kitamura, Ryo, Sekimoto, Toshihiro, Ito, Sayuri, Harada, Shizuko, Yamagata, Hideo, Masai, Hisao, Yoneda, Yoshihiro, Yanagi, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367128/
https://ncbi.nlm.nih.gov/pubmed/16439554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.4.1979-1991.2006
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