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Bistability Explains Threshold Phenomena in Protein Aggregation both In Vitro and In Vivo
Neurodegenerative disease can originate from the misfolding and aggregation of proteins, such as Amyloid-β, SOD1, or Huntingtin. Fortunately, all cells possess protein quality control machinery that sequesters misfolded proteins, either refolding or degrading them, before they can self-associate int...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Biophysical Society
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1367113/ https://ncbi.nlm.nih.gov/pubmed/16299080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.066662 |
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