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An Energy-Efficient Gating Mechanism in the Acetylcholine Receptor Channel Suggested by Molecular and Brownian Dynamics
Acetylcholine receptors mediate electrical signaling between nerve and muscle by opening and closing a transmembrane ion conductive pore. Molecular and Brownian dynamics simulations are used to shed light on the location and mechanism of the channel gate. Four separate 5 ns molecular dynamics simula...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Biophysical Society
2006
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1367105/ https://ncbi.nlm.nih.gov/pubmed/16284265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.067868 |
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