Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters

The penetration of telavancin was 2% into inflamed meninges and ca. 1‰ into noninflamed meninges after two intravenous injections (30 mg/kg of body weight). In experimental meningitis, telavancin was significantly superior to vancomycin combined with ceftriaxone against a penicillin-resistant pneumo...

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Main Authors: Stucki, Armin, Gerber, Peter, Acosta, Fernando, Cottagnoud, Marianne, Cottagnoud, Philippe
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366883/
https://ncbi.nlm.nih.gov/pubmed/16436742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.2.770-773.2006
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