Mechanism of De Novo Initiation by the Hepatitis C Virus RNA-Dependent RNA Polymerase: Role of Divalent Metals

We functionally analyzed the role of metal ions in RNA-dependent RNA synthesis by three recombinant RNA-dependent RNA polymerases (RdRps) from GB virus-B (GBV), bovine viral diarrhea virus (BVDV), and hepatitis C virus (HCV), with emphasis on the HCV RdRp. Using templates capable of both de novo ini...

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Publié dans:	J Virol
Auteurs principaux:	Ranjith-Kumar, C. T., Kim, Young-Chan, Gutshall, Les, Silverman, Carol, Khandekar, Sanjay, Sarisky, Robert T., Kao, C. Cheng
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2002
Sujets:	Replication
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136676/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12438577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.24.12513-12525.2002
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