Mechanism of De Novo Initiation by the Hepatitis C Virus RNA-Dependent RNA Polymerase: Role of Divalent Metals

We functionally analyzed the role of metal ions in RNA-dependent RNA synthesis by three recombinant RNA-dependent RNA polymerases (RdRps) from GB virus-B (GBV), bovine viral diarrhea virus (BVDV), and hepatitis C virus (HCV), with emphasis on the HCV RdRp. Using templates capable of both de novo ini...

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Bibliografiska uppgifter
Huvudupphovsmän: Ranjith-Kumar, C. T., Kim, Young-Chan, Gutshall, Les, Silverman, Carol, Khandekar, Sanjay, Sarisky, Robert T., Kao, C. Cheng
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2002
Ämnen:
Replication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC136676/
https://ncbi.nlm.nih.gov/pubmed/12438577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.24.12513-12525.2002
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