Signaling through Receptors and Scaffolds: Independent Interactions Reduce Combinatorial Complexity

After activation, many receptors and their adaptor proteins act as scaffolds displaying numerous docking sites and engaging multiple targets. The consequent assemblage of a variety of protein complexes results in a combinatorial increase in the number of feasible molecular species presenting differe...

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Bibliographic Details
Main Authors: Borisov, Nikolay M., Markevich, Nick I., Hoek, Jan B., Kholodenko, Boris N.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2005
Subjects:
Biophysical Theory and Modeling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366644/
https://ncbi.nlm.nih.gov/pubmed/15923229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.060533
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