Nuclear Localization of Human Immunodeficiency Virus Type 1 Preintegration Complexes (PICs): V165A and R166A Are Pleiotropic Integrase Mutants Primarily Defective for Integration, Not PIC Nuclear Import

Retroviral replication requires the integration of reverse-transcribed viral cDNA into a cell chromosome. A key barrier to forming the integrated provirus is the nuclear envelope, and numerous regions in human immunodeficiency virus type 1 (HIV-1) have been shown to aid the nuclear localization of v...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Limón, Ana, Devroe, Eric, Lu, Richard, Ghory, Hina Z., Silver, Pamela A., Engelman, Alan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136649/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12368302/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.21.10598-10607.2002
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