Nuclear Localization of Human Immunodeficiency Virus Type 1 Preintegration Complexes (PICs): V165A and R166A Are Pleiotropic Integrase Mutants Primarily Defective for Integration, Not PIC Nuclear Import

Retroviral replication requires the integration of reverse-transcribed viral cDNA into a cell chromosome. A key barrier to forming the integrated provirus is the nuclear envelope, and numerous regions in human immunodeficiency virus type 1 (HIV-1) have been shown to aid the nuclear localization of v...

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Autores principales: Limón, Ana, Devroe, Eric, Lu, Richard, Ghory, Hina Z., Silver, Pamela A., Engelman, Alan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC136649/
https://ncbi.nlm.nih.gov/pubmed/12368302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.21.10598-10607.2002
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