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A New Type of Adenovirus Vector That Utilizes Homologous Recombination To Achieve Tumor-Specific Replication
We have developed a new class of adenovirus vectors that selectively replicate in tumor cells. The vector design is based on our recent observation that a variety of human tumor cell lines support DNA replication of adenovirus vectors with deletions of the E1A and E1B genes, whereas primary human ce...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC136641/ https://ncbi.nlm.nih.gov/pubmed/12368342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.21.10994-11002.2002 |
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