A New Type of Adenovirus Vector That Utilizes Homologous Recombination To Achieve Tumor-Specific Replication

We have developed a new class of adenovirus vectors that selectively replicate in tumor cells. The vector design is based on our recent observation that a variety of human tumor cell lines support DNA replication of adenovirus vectors with deletions of the E1A and E1B genes, whereas primary human ce...

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Sonraí Bibleagrafaíochta
Main Authors: Bernt, Kathrin, Liang, Min, Ye, Xun, Ni, Shaoheng, Li, Zong-Yi, Ye, Sheng Long, Hu, Fang, Lieber, André
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2002
Ábhair:
Gene Therapy
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC136641/
https://ncbi.nlm.nih.gov/pubmed/12368342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.21.10994-11002.2002
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