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Optimized Chimeras between Kinase-Inactive Mutant Cdk9 and Truncated Cyclin T1 Proteins Efficiently Inhibit Tat Transactivation and Human Immunodeficiency Virus Gene Expression

The human cyclin T1 (hCycT1) protein from the positive transcription elongation factor b (P-TEFb) binds the transactivator Tat and the transactivation response (TAR) RNA stem loop from human immunodeficiency virus type 1 (HIV). This complex activates the elongation of viral transcription. To create...

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Autors principals: Fujinaga, Koh, Irwin, Dan, Geyer, Matthias, Peterlin, B. Matija
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC136629/
https://ncbi.nlm.nih.gov/pubmed/12368330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.21.10873-10881.2002
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