Optimized Chimeras between Kinase-Inactive Mutant Cdk9 and Truncated Cyclin T1 Proteins Efficiently Inhibit Tat Transactivation and Human Immunodeficiency Virus Gene Expression

The human cyclin T1 (hCycT1) protein from the positive transcription elongation factor b (P-TEFb) binds the transactivator Tat and the transactivation response (TAR) RNA stem loop from human immunodeficiency virus type 1 (HIV). This complex activates the elongation of viral transcription. To create...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Fujinaga, Koh, Irwin, Dan, Geyer, Matthias, Peterlin, B. Matija
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136629/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12368330/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.21.10873-10881.2002
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