Optimized Chimeras between Kinase-Inactive Mutant Cdk9 and Truncated Cyclin T1 Proteins Efficiently Inhibit Tat Transactivation and Human Immunodeficiency Virus Gene Expression

The human cyclin T1 (hCycT1) protein from the positive transcription elongation factor b (P-TEFb) binds the transactivator Tat and the transactivation response (TAR) RNA stem loop from human immunodeficiency virus type 1 (HIV). This complex activates the elongation of viral transcription. To create...

Description complète

Détails bibliographiques

Publié dans:	J Virol
Auteurs principaux:	Fujinaga, Koh, Irwin, Dan, Geyer, Matthias, Peterlin, B. Matija
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2002
Sujets:	Vaccines and Antiviral Agents
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136629/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12368330/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.21.10873-10881.2002
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!