Simian Virus 40 Small Tumor Antigen Activates AKT and Telomerase and Induces Anchorage-Independent Growth of Human Epithelial Cells

Human keratinocytes immortalized by full-length or early-region simian virus 40 (SV40) DNA grow in agarose and form tumors in nude mice, in contrast to keratinocytes immortalized by the E6/E7 genes of human papillomaviruses. To determine the molecular basis for this biological difference in growth,...

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Detalhes bibliográficos
Main Authors: Yuan, Hang, Veldman, Tim, Rundell, Kathleen, Schlegel, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Transformation and Oncogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136600/
https://ncbi.nlm.nih.gov/pubmed/12368310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.21.10685-10691.2002
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