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Insertions in the Reverse Transcriptase Increase both Drug Resistance and Viral Fitness in a Human Immunodeficiency Virus Type 1 Isolate Harboring the Multi-Nucleoside Reverse Transcriptase Inhibitor Resistance 69 Insertion Complex Mutation

Recent studies have shown that the accumulation of multiple mutations associated with nucleoside reverse transcriptase inhibitor (NRTI) resistance may be grouped as multi-NRTI resistance (MNR) complexes. In this study, we have examined the viral fitness of recombinant viruses carrying the reverse tr...

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Published in:J Virol
Main Authors: Quiñones-Mateu, Miguel E., Tadele, Mahlet, Parera, Mariona, Mas, Antonio, Weber, Jan, Rangel, Héctor R., Chakraborty, Bikram, Clotet, Bonaventura, Domingo, Esteban, Menéndez-Arias, Luis, Martínez, Miguel A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2002
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136580/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12239335/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.20.10546-10552.2002
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