Study of Antigen-Processing Steps Reveals Preferences Explaining Differential Biological Outcomes of Two HLA-A2-Restricted Immunodominant Epitopes from Human Immunodeficiency Virus Type 1

Cytotoxic T-lymphocyte (CTL) responses directed to different human immunodeficiency virus (HIV) epitopes vary in their protective efficacy. In particular, HIV-infected cells are much more sensitive to lysis by anti-Gag/p17(77-85)/HLA-A2 than to that by anti-polymerase/RT(476-484)/HLA-A2 CTL, because...

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Detalhes bibliográficos
Main Authors: Cohen, W. M., Bianco, A., Connan, F., Camoin, L., Dalod, M., Lauvau, G., Ferriès, E., Culmann-Penciolelli, B., van Endert, P. M., Briand, J. P., Choppin, J., Guillet, J. G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136577/
https://ncbi.nlm.nih.gov/pubmed/12239297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.20.10219-10225.2002
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