Adaptation of Alphaviruses to Heparan Sulfate: Interaction of Sindbis and Semliki Forest Viruses with Liposomes Containing Lipid-Conjugated Heparin

Passage of Sindbis virus (SIN) in BHK-21 cells has been shown to select for virus mutants with high affinity for the glycosaminoglycan heparan sulfate (HS). Three loci in the viral spike protein E2 (E2:1, E2:70, and E2:114) have been identified that mutate during adaptation and independently confer...

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הוצא לאור ב:	J Virol
Principais autores:	Smit, Jolanda M., Waarts, Barry-Lee, Kimata, Koji, Klimstra, William B., Bittman, Robert, Wilschut, Jan
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 2002
נושאים:	Virus-Cell Interactions
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136541/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12239287/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.20.10128-10137.2002
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