A Prenylation Inhibitor Prevents Production of Infectious Hepatitis Delta Virus Particles

Hepatitis delta virus (HDV) causes both acute and chronic liver disease throughout the world. Effective medical therapy is lacking. Previous work has shown that the assembly of HDV virus-like particles (VLPs) could be abolished by BZA-5B, a compound with farnesyltransferase inhibitory activity. Here...

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Autors principals: Bordier, Bruno B., Marion, Patricia L., Ohashi, Kazuo, Kay, Mark A., Greenberg, Harry B., Casey, John L., Glenn, Jeffrey S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC136538/
https://ncbi.nlm.nih.gov/pubmed/12239323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.20.10465-10472.2002
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