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Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth

Suboptimal axonal regeneration contributes to the consequences of nervous system trauma and neurodegenerative disease, but the intrinsic mechanisms that regulate axon growth remain unclear. We screened 50,400 small molecules for their ability to promote axon outgrowth on inhibitory substrata. The mo...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Hai Li, Takaaki Kuwajima, Derek Oakley, Elena Nikulina, Jianwei Hou, Wan Seok Yang, Emily Rhodes Lowry, Nuno Jorge Lamas, Mackenzie Weygandt Amoroso, Gist F. Croft, Raghavendra Hosur, Hynek Wichterle, Said Sebti, Marie T. Filbin, Brent Stockwell, Christopher E. Henderson
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016-07-01
Schriftenreihe:Cell Reports
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211124716307379
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