Vigabatrin-induced decrease in serum phenytoin concentration does not involve a change in phenytoin bioavailability.

The possibility that vigabatrin (VGB) decreases serum phenytoin (PHT) concentration by lowering the oral bioavailability of PHT was investigated in 21 patients with epilepsy. Each patient was switched from oral to intravenous PHT for 5 days before and after combined treatment with VGB. After VGB (2-...

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Main Authors: Gatti, G, Bartoli, A, Marchiselli, R, Michelucci, R, Tassinari, C A, Pisani, F, Zaccara, G, Timmings, P, Richens, A, Perucca, E
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1364668/
https://ncbi.nlm.nih.gov/pubmed/12959280
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