Effect of valproate on free plasma phenytoin concentrations.

The plasma protein binding of phenytoin was studied in nine epileptic patients before and during addition of sodium valproate to the drug therapy. The free phenytoin fraction in plasma was significantly greater during sodium valproate treatment. The mean free fraction rose from 0.135 +/- 0.019 (s.d....

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Bibliografiske detaljer
Main Authors: Tsanaclis, L M, Allen, J, Perucca, E, Routledge, P A, Richens, A
Format: Artigo
Sprog:Inglês
Udgivet: 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463568/
https://ncbi.nlm.nih.gov/pubmed/6430316
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