Overexpression of Interleukin-2 by a Recombinant Herpes Simplex Virus Type 1 Attenuates Pathogenicity and Enhances Antiviral Immunity

The expression of interleukin-2 (IL-2) has been implicated in the modulation of the outcome of ocular infection with herpes simplex virus type 1 (HSV-1); however, its effects remain controversial. To clarify the role of IL-2, we constructed a recombinant HSV-1 (HSV-IL-2) that expresses two copies of...

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Vydáno v:	J Virol
Hlavní autoři:	Ghiasi, Homayon, Osorio, Yanira, Perng, Guey-Chuen, Nesburn, Anthony B., Wechsler, Steven L.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2002
Témata:	Pathogenesis and Immunity
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136420/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12186890/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.18.9069-9078.2002
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