Overexpression of Interleukin-2 by a Recombinant Herpes Simplex Virus Type 1 Attenuates Pathogenicity and Enhances Antiviral Immunity

The expression of interleukin-2 (IL-2) has been implicated in the modulation of the outcome of ocular infection with herpes simplex virus type 1 (HSV-1); however, its effects remain controversial. To clarify the role of IL-2, we constructed a recombinant HSV-1 (HSV-IL-2) that expresses two copies of...

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Bibliographische Detailangaben
Hauptverfasser: Ghiasi, Homayon, Osorio, Yanira, Perng, Guey-Chuen, Nesburn, Anthony B., Wechsler, Steven L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC136420/
https://ncbi.nlm.nih.gov/pubmed/12186890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.18.9069-9078.2002
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