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Immunogenicity and Tolerogenicity of Hepatitis B Virus Structural and Nonstructural Proteins: Implications for Immunotherapy of Persistent Viral Infections

Persistent hepatitis B virus (HBV) infection is characterized by a weak and narrowly focused CD8(+) T-cell response to HBV that is thought to reflect the induction of central and/or peripheral tolerance to HBV proteins in neonatal and adult onset infections, respectively. Immunotherapeutic strategie...

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Main Authors: Kakimi, Kazuhiro, Isogawa, Masanori, Chung, JoSan, Sette, Alessandro, Chisari, Francis V.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136410/
https://ncbi.nlm.nih.gov/pubmed/12163580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.17.8609-8620.2002
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