Genetic Evidence that Interhelical Packing Interactions in the gp41 Core Are Critical for Transition of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein to the Fusion-Active State

The envelope glycoprotein complex (gp120-gp41) of human immunodeficiency virus type 1 (HIV-1) promotes the fusion of viral and cellular membranes through formation of the fusion-active six-helix bundle in the gp41 ectodomain. This gp41 core structure consists of three C-terminal helices packed in an...

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Pubblicato in:	J Virol
Autori principali:	Follis, Kathryn E., Larson, Scott J., Lu, Min, Nunberg, Jack H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Virus-Cell Interactions
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12072535/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.14.7356-7362.2002
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