Herpes Simplex Virus Type 1/Adeno-Associated Virus rep(+) Hybrid Amplicon Vector Improves the Stability of Transgene Expression in Human Cells by Site-Specific Integration

Herpes simplex virus type 1 (HSV-1) amplicon vectors are promising gene delivery tools, but their utility in gene therapy has been impeded to some extent by their inability to achieve stable transgene expression. In this study, we examined the possibility of improving transduction stability in cultu...

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Detalhes bibliográficos
Main Authors: Wang, Y., Camp, S. M., Niwano, M., Shen, X., Bakowska, J. C., Breakefield, X. O., Allen, P. D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136298/
https://ncbi.nlm.nih.gov/pubmed/12072515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.14.7150-7162.2002
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