Herpes Simplex Virus Type 1/Adeno-Associated Virus Hybrid Vectors Mediate Site-Specific Integration at the Adeno-Associated Virus Preintegration Site, AAVS1, on Human Chromosome 19

Herpes simplex virus type 1 (HSV-1)-based amplicon vectors have a large transgene capacity and can efficiently infect many different cell types. One disadvantage of HSV-1 vectors is their instability of transgene expression. By contrast, vectors based on adeno-associated virus (AAV) can either persi...

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Autors principals: Heister, Thomas, Heid, Irma, Ackermann, Mathias, Fraefel, Cornel
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC136299/
https://ncbi.nlm.nih.gov/pubmed/12072516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.14.7163-7173.2002
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