Three Regions of the pRB Pocket Domain Affect Its Inactivation by Human Papillomavirus E7 Proteins
A critical event in papillomavirus transformation of human cells is the inactivation of pRB by the E7 protein. E7, like many other viral oncoproteins, possesses a well-characterized LXCXE peptide motif that interacts with the pocket domain of pRB. Disruption of the LXCXE-binding cleft on pRB renders...
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| Publicado no: | J Virol |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136242/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12021356/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.12.6224-6234.2002 |
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