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Three Regions of the pRB Pocket Domain Affect Its Inactivation by Human Papillomavirus E7 Proteins
A critical event in papillomavirus transformation of human cells is the inactivation of pRB by the E7 protein. E7, like many other viral oncoproteins, possesses a well-characterized LXCXE peptide motif that interacts with the pocket domain of pRB. Disruption of the LXCXE-binding cleft on pRB renders...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC136242/ https://ncbi.nlm.nih.gov/pubmed/12021356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.12.6224-6234.2002 |
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