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Physiological and Pathological Changes in Glucose Regulate Brain Akt and Glycogen Synthase Kinase-3

Insulin regulates the phosphorylation and activities of Akt and glycogen synthase kinase-3 (GSK3) in peripheral tissues, but in the brain it is less clear how this signaling pathway is regulated in vivo and whether it is affected by diabetes. We found that Akt and GSK3 are sensitive to glucose, beca...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Clodfelder-Miller, Buffie, De Sarno, Patrizia, Zmijewska, Anna A., Song, Ling, Jope, Richard S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1361688/
https://ncbi.nlm.nih.gov/pubmed/16179343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M508824200
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