Cytopathic Killing of Peripheral Blood CD4(+) T Lymphocytes by Human Immunodeficiency Virus Type 1 Appears Necrotic rather than Apoptotic and Does Not Require env

An important unresolved issue of AIDS pathogenesis is the mechanism of human immunodeficiency virus (HIV)-induced CD4(+) T-lymphocyte destruction. We show here that HIV type 1 (HIV-1) exerts a profound cytopathic effect upon peripheral blood CD4(+) T lymphocytes that resembles necrosis rather than a...

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Detalhes bibliográficos
Main Authors: Lenardo, Michael J., Angleman, Sara B., Bounkeua, Viengngeun, Dimas, Joseph, Duvall, Melody G., Graubard, Moses B., Hornung, Felicita, Selkirk, Marianne C., Speirs, Christina K., Trageser, Carol, Orenstein, Jan O., Bolton, Diane L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136142/
https://ncbi.nlm.nih.gov/pubmed/11967324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.10.5082-5093.2002
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