Cytopathic Killing of Peripheral Blood CD4(+) T Lymphocytes by Human Immunodeficiency Virus Type 1 Appears Necrotic rather than Apoptotic and Does Not Require env

An important unresolved issue of AIDS pathogenesis is the mechanism of human immunodeficiency virus (HIV)-induced CD4(+) T-lymphocyte destruction. We show here that HIV type 1 (HIV-1) exerts a profound cytopathic effect upon peripheral blood CD4(+) T lymphocytes that resembles necrosis rather than a...

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Bibliografische gegevens
Hoofdauteurs: Lenardo, Michael J., Angleman, Sara B., Bounkeua, Viengngeun, Dimas, Joseph, Duvall, Melody G., Graubard, Moses B., Hornung, Felicita, Selkirk, Marianne C., Speirs, Christina K., Trageser, Carol, Orenstein, Jan O., Bolton, Diane L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2002
Onderwerpen:
Virus-Cell Interactions
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC136142/
https://ncbi.nlm.nih.gov/pubmed/11967324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.10.5082-5093.2002
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