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A Protein Encoded by the Herpes Simplex Virus (HSV) Type 1 2-Kilobase Latency-Associated Transcript Is Phosphorylated, Localized to the Nucleus, and Overcomes the Repression of Expression from Exogenous Promoters When Inserted into the Quiescent HSV Genome

Herpes simplex virus (HSV) is characterized by its ability to establish a latent infection in sensory neurons, from which it can periodically reactivate. The mechanisms of latency, however, remain unclear. The HSV genome is quiescent during latency except for the expression of the latency-associated...

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Detalhes bibliográficos
Main Authors: Thomas, S. K., Lilley, C. E., Latchman, D. S., Coffin, R. S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136061/
https://ncbi.nlm.nih.gov/pubmed/11907244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.8.4056-4067.2002
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