The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.

During herpes simplex virus type 1 (HSV-1) neuronal latency, the only viral RNA detected is from the latency-associated transcript (LAT) gene. We have made a LAT deletion mutant of McKrae, an HSV-1 strain with a very high in vivo spontaneous reactivation rate. This mutant (dLAT2903) lacks the LAT pr...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Perng, G C, Dunkel, E C, Geary, P A, Slanina, S M, Ghiasi, H, Kaiwar, R, Nesburn, A B, Wechsler, S L
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237268/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7966594/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.12.8045-8055.1994
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