The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.

During herpes simplex virus type 1 (HSV-1) neuronal latency, the only viral RNA detected is from the latency-associated transcript (LAT) gene. We have made a LAT deletion mutant of McKrae, an HSV-1 strain with a very high in vivo spontaneous reactivation rate. This mutant (dLAT2903) lacks the LAT pr...

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Hlavní autoři: Perng, G C, Dunkel, E C, Geary, P A, Slanina, S M, Ghiasi, H, Kaiwar, R, Nesburn, A B, Wechsler, S L
Médium: Artigo
Jazyk:Inglês
Vydáno: 1994
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC237268/
https://ncbi.nlm.nih.gov/pubmed/7966594
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