Induction of In Vivo Antipolysaccharide Immunoglobulin Responses to Intact Streptococcus pneumoniae Is More Heavily Dependent on Btk-Mediated B-Cell Receptor Signaling than Antiprotein Responses

The relative role of Btk-dependent B-cell receptor (BCR) signaling in the induction of antipolysaccharide (anti-PS) and antiprotein immunoglobulin (Ig) responses to an intact extracellular bacterium in vivo is unknown. Btk(low) mice exhibit reduced BCR signaling but largely restore B-cell developmen...

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Detalhes bibliográficos
Main Authors: Khan, Abdul Q., Sen, Goutam, Guo, Shuling, Witte, Owen N., Snapper, Clifford M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360338/
https://ncbi.nlm.nih.gov/pubmed/16428797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.2.1419-1424.2006
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