Differential idiotype utilization for the in vivo type 14 capsular polysaccharide-specific immunoglobulin responses to intact Streptococcus pneumoniae versus a pneumococcal conjugate vaccine

Murine IgG responses specific for the capsular polysaccharide (PPS14) of Streptococcus pneumoniae type 14 (Pn14) induced in response to intact Pn14 or a PPS14-protein conjugate are both dependent on CD4+ T cell help, but appear to utilize marginal zone versus follicular B cells, respectively. Here w...

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Detalhes bibliográficos
Main Authors: Colino, Jesus, Duke, Leah, Arjunaraja, Swadhinya, Chen, Quanyi, Liu, Leyu, Lucas, Alexander H., Snapper, Clifford M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392520/
https://ncbi.nlm.nih.gov/pubmed/22706079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200599
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