Construction and Phase I Clinical Evaluation of the Safety and Immunogenicity of a Candidate Enterotoxigenic Escherichia coli Vaccine Strain Expressing Colonization Factor Antigen CFA/I

Oral delivery of toxin-negative derivatives of enterotoxigenic Escherichia coli (ETEC) that express colonization factor antigens (CFA) with deletions of the aroC, ompC, ompF, and toxin genes may be an effective approach to vaccination against ETEC-associated diarrhea. We describe the creation and ch...

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Detalhes bibliográficos
Main Authors: Turner, Arthur K., Beavis, Juliet C., Stephens, Jonathan C., Greenwood, Judith, Gewert, Cornelia, Thomas, Nicola, Deary, Alison, Casula, Gabriella, Daley, Alexandra, Kelly, Paul, Randall, Roger, Darsley, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360332/
https://ncbi.nlm.nih.gov/pubmed/16428753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.2.1062-1071.2006
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