Construction and Phase I Clinical Evaluation of the Safety and Immunogenicity of a Candidate Enterotoxigenic Escherichia coli Vaccine Strain Expressing Colonization Factor Antigen CFA/I

Oral delivery of toxin-negative derivatives of enterotoxigenic Escherichia coli (ETEC) that express colonization factor antigens (CFA) with deletions of the aroC, ompC, ompF, and toxin genes may be an effective approach to vaccination against ETEC-associated diarrhea. We describe the creation and ch...

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Bibliographische Detailangaben
Hauptverfasser: Turner, Arthur K., Beavis, Juliet C., Stephens, Jonathan C., Greenwood, Judith, Gewert, Cornelia, Thomas, Nicola, Deary, Alison, Casula, Gabriella, Daley, Alexandra, Kelly, Paul, Randall, Roger, Darsley, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360332/
https://ncbi.nlm.nih.gov/pubmed/16428753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.2.1062-1071.2006
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