Effects of Valproic Acid Derivatives on Inositol Trisphosphate Depletion, Teratogenicity, Glycogen Synthase Kinase-3β Inhibition, and Viral Replication: A Screening Approach for New Bipolar Disorder Drugs Derived from the Valproic Acid Core Structure

Inositol-1,4,5-trisphosphate (InsP(3)) depletion has been implicated in the therapeutic action of bipolar disorder drugs, including valproic acid (VPA). It is not currently known whether the effect of VPA on InsP(3) depletion is related to the deleterious effects of teratogenicity or elevated viral...

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Autori principali: Eickholt, B. J., Towers, G. J., Ryves, W. J., Eikel, D., Adley, K., Ylinen, L. M. J., Chadborn, N. H., Harwood, A. J., Nau, H., Williams, R. S. B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360212/
https://ncbi.nlm.nih.gov/pubmed/15687223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.104.009308
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