Efficient and Selective Gene Transfer into Primary Human Brain Tumors by Using Single-Chain Antibody-Targeted Adenoviral Vectors with Native Tropism Abolished

The application of adenoviral vectors in cancer gene therapy is hampered by low receptor expression on tumor cells and high receptor expression on normal epithelial cells. Targeting adenoviral vectors toward tumor cells may improve cancer gene therapy procedures by providing augmented tumor transduc...

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Detalhes bibliográficos
Main Authors: van Beusechem, Victor W., Grill, Jacques, Mastenbroek, D. C. Jeroen, Wickham, Thomas J., Roelvink, Peter W., Haisma, Hidde J., Lamfers, Martine L. M., Dirven, Clemens M. F., Pinedo, Herbert M., Gerritsen, Winald R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135966/
https://ncbi.nlm.nih.gov/pubmed/11861842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.6.2753-2762.2002
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