Single Mutation in the Flavivirus Envelope Protein Hinge Region Increases Neurovirulence for Mice and Monkeys but Decreases Viscerotropism for Monkeys: Relevance to Development and Safety Testing of Live, Attenuated Vaccines

A chimeric yellow fever (YF) virus/Japanese encephalitis (JE) virus vaccine (ChimeriVax-JE) was constructed by insertion of the prM-E genes from the attenuated JE virus SA14-14-2 vaccine strain into a full-length cDNA clone of YF 17D virus. Passage in fetal rhesus lung (FRhL) cells led to the emerge...

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Главные авторы: Monath, Thomas P., Arroyo, Juan, Levenbook, Inessa, Zhang, Zhen-Xi, Catalan, John, Draper, Ken, Guirakhoo, Farshad
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2002
Предметы:
Vaccines and Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC135909/
https://ncbi.nlm.nih.gov/pubmed/11799188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.1932-1943.2002
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