Single Mutation in the Flavivirus Envelope Protein Hinge Region Increases Neurovirulence for Mice and Monkeys but Decreases Viscerotropism for Monkeys: Relevance to Development and Safety Testing of Live, Attenuated Vaccines

A chimeric yellow fever (YF) virus/Japanese encephalitis (JE) virus vaccine (ChimeriVax-JE) was constructed by insertion of the prM-E genes from the attenuated JE virus SA14-14-2 vaccine strain into a full-length cDNA clone of YF 17D virus. Passage in fetal rhesus lung (FRhL) cells led to the emerge...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	J Virol
Autori principali:	Monath, Thomas P., Arroyo, Juan, Levenbook, Inessa, Zhang, Zhen-Xi, Catalan, John, Draper, Ken, Guirakhoo, Farshad
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Vaccines and Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135909/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11799188/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.4.1932-1943.2002
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!