載入...

Single Mutation in the Flavivirus Envelope Protein Hinge Region Increases Neurovirulence for Mice and Monkeys but Decreases Viscerotropism for Monkeys: Relevance to Development and Safety Testing of Live, Attenuated Vaccines

A chimeric yellow fever (YF) virus/Japanese encephalitis (JE) virus vaccine (ChimeriVax-JE) was constructed by insertion of the prM-E genes from the attenuated JE virus SA14-14-2 vaccine strain into a full-length cDNA clone of YF 17D virus. Passage in fetal rhesus lung (FRhL) cells led to the emerge...

全面介紹

Na minha lista:

書目詳細資料
Main Authors:	Monath, Thomas P., Arroyo, Juan, Levenbook, Inessa, Zhang, Zhen-Xi, Catalan, John, Draper, Ken, Guirakhoo, Farshad
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology 2002
主題:	Vaccines and Antiviral Agents
在線閱讀:	https://ncbi.nlm.nih.gov/pmc/articles/PMC135909/ https://ncbi.nlm.nih.gov/pubmed/11799188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.1932-1943.2002
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

Single Mutation in the Flavivirus Envelope Protein Hinge Region Increases Neurovirulence for Mice and Monkeys but Decreases Viscerotropism for Monkeys: Relevance to Development and Safety Testing of Live, Attenuated Vaccines

相似書籍