Single Mutation in the Flavivirus Envelope Protein Hinge Region Increases Neurovirulence for Mice and Monkeys but Decreases Viscerotropism for Monkeys: Relevance to Development and Safety Testing of Live, Attenuated Vaccines

A chimeric yellow fever (YF) virus/Japanese encephalitis (JE) virus vaccine (ChimeriVax-JE) was constructed by insertion of the prM-E genes from the attenuated JE virus SA14-14-2 vaccine strain into a full-length cDNA clone of YF 17D virus. Passage in fetal rhesus lung (FRhL) cells led to the emerge...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Monath, Thomas P., Arroyo, Juan, Levenbook, Inessa, Zhang, Zhen-Xi, Catalan, John, Draper, Ken, Guirakhoo, Farshad
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC135909/
https://ncbi.nlm.nih.gov/pubmed/11799188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.1932-1943.2002
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky