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Frequency of Missense Mutations in the Coding Region of a Eukaryotic Gene Transferred by Retroviral Vectors

A relatively high mutation rate is probably a major factor in the evolutionary success of retroviruses, because it generates the genetic diversity that helps them to cope with changes in the environment. When using recombinant retroviruses as vectors for gene transfer and gene therapy, it is importa...

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Hlavní autoři: Angioletti, Maria De, Rovira, Ana, Sadelain, Michel, Luzzatto, Lucio, Notaro, Rosario
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC135901/
https://ncbi.nlm.nih.gov/pubmed/11799194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.1991-1994.2002
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